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 Oncology & Cell Fate

PNC-27

PNC-27 is a synthetic peptide consisting of a defined amino acid sequence. It is supplied in lyophilized powder form to support purity and stability in laboratory environments. PNC-27 is intended strictly for controlled in vitro laboratory research by qualified professionals.

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Product Usage: Not for Human or Veterinary UsePure Health Peptides products are supplied to qualified research professionals and institutional users for in vitro laboratory research only. KYC verification is required prior to order fulfillment, and we reserve the right to refuse orders that do not meet buyer qualification criteria. These products are not drugs, foods, cosmetics, diagnostic products, or dietary supplements, have not been evaluated by the FDA, and are not intended for human or animal use. Any such use is prohibited and may violate federal, state, or local law. By purchasing, the buyer represents and warrants that the product will be used solely for in vitro research. The buyer agrees to indemnify, defend, and hold harmless Pure Health Peptides, its officers, employees, and agents from and against any and all claims, damages, losses, liabilities, costs, and expenses (including reasonable attorneys fees) arising out of or relating to the buyer’s use, handling, storage, or disposition of the product in any manner inconsistent with its research-use-only designation or applicable law.

Description

Product Name:

PNC-27

Chemical Information:
  • Molecular Formula: C188H293N53O44S
  • Molecular Weight: 4031.7 g/mol
  • Sequence: PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG
  • Structure Class: Energy minimized structure of PNC-27
Molecular Structure:



Molecular Structure

Product Description:

PNC-27 is a synthetic peptide consisting of a defined amino acid sequence. It is supplied in lyophilized powder form to support purity and stability in laboratory environments. PNC-27 is intended strictly for controlled in vitro laboratory research by qualified professionals.

Research Applications:
  • Characterization of peptide structural properties in vitro
  • Analysis of peptide stability and degradation profiles
  • Evaluation of physicochemical properties of synthetic peptide compounds
  • Investigation of peptide behavior under controlled laboratory conditions
  • Analytical assessment of peptide consistency and composition

 

Storage and Handling:

  • Store lyophilized powder at −20 °C until use
  • After reconstitution, store at 2–8 °C and use promptly
  • Use aseptic techniques during handling and reconstitution

Product Specifications:

  • Purity: ≥99% (HPLC Certified)
  • Appearance: Lyophilized white to off-white powder
  • Solubility: Soluble in suitable laboratory agents
Compliance Notice:

PNC-27 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes

Certificate of Analysis

Certificate of Analysis

At Pure Health Peptides, transparency is key. Every batch is third-party tested in the USA, with Certificates of Analysis (COAs) readily available for verification, giving researchers confidence in their work.

View Certifications

Frequently Asked Questions

What is PNC-27?
PNC-27 is a synthetic 32-amino-acid peptide (sequence PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG) consisting of a segment corresponding to residues 12-26 of the p53 protein joined to a membrane-residency peptide. It has CAS number 1159861-00-3, molecular formula C188H293N53O44S, and a molecular weight of approximately 4032 g/mol. Pure Health Peptides supplies it as a lyophilized powder strictly for in vitro laboratory research.
What is the membrane-residency peptide portion?
The membrane-residency peptide is the C-terminal segment of PNC-27. Research literature reports that this portion directs the peptide to cell membranes, positioning the p53-derived segment for the interactions studied in cell-based models. It is a structural targeting element of the construct.
What is PNC-27 studied for in research?
In controlled laboratory settings, PNC-27 is studied as a p53-derived peptide. Research literature reports that the p53-derived segment corresponds to the region that binds HDM-2, and that the construct has been examined in in-vitro studies for membrane-disrupting activity in cancer-cell line models. No claim is made regarding activity in humans or animals. These are research findings; all applications are non-clinical.
What are PNC-27's chemical specifications, and what size does it come in?
PNC-27 has CAS number 1159861-00-3, the molecular formula C188H293N53O44S, and a molecular weight of approximately 4032 g/mol (refer to the lot-specific Certificate of Analysis for the exact value). It is supplied as a lyophilized powder in 5 mg and 10 mg sizes at greater than or equal to 98% purity (HPLC). Store in a cool, dry place away from light and moisture, and consult the Safety Data Sheet before handling.
Where can I buy PNC-27, and is it third-party tested?
PNC-27 is available from Pure Health Peptides as research-grade material in 5 mg and 10 mg sizes at greater than or equal to 98% HPLC-verified purity. Every production lot is third-party tested in the US, with a lot-specific Certificate of Analysis available for verification.
Is PNC-27 intended for human or clinical use?
No. PNC-27 is for research use only and is not intended for human or veterinary use. It has not been evaluated by the FDA and is not a drug, food, cosmetic, or dietary supplement. It is supplied only to qualified research professionals for in vitro laboratory research, and KYC verification is required prior to fulfillment. Any use outside of controlled in vitro research is strictly prohibited.