First Time Customer? First Time Order? Get your 25% Off [Click Here]
 Regeneration & Aging Research, Neuroscience & Cognition

PE-22-28

PE-22-28 is a synthetic heptapeptide corresponding to residues 22–28 of spadin, a naturally occurring peptide fragment derived from the sortilin propeptide. The sequence represents a shortened analogue of the parent peptide. PE-22-28 is produced via solid-phase peptide synthesis (SPPS) and supplied as a lyophilized powder intended exclusively for controlled in-vitro laboratory research by qualified professionals. This product is not formulated for clinical, diagnostic, or therapeutic use.

In stock
Select Weight
Select Amount
1
$43.00Order more, save more

Add 1 more for 2% off.

Free Shipping on All Orders $175+

Product Usage: Not for Human or Veterinary UsePure Health Peptides products are supplied to qualified research professionals and institutional users for in vitro laboratory research only. KYC verification is required prior to order fulfillment, and we reserve the right to refuse orders that do not meet buyer qualification criteria. These products are not drugs, foods, cosmetics, diagnostic products, or dietary supplements, have not been evaluated by the FDA, and are not intended for human or animal use. Any such use is prohibited and may violate federal, state, or local law. By purchasing, the buyer represents and warrants that the product will be used solely for in vitro research. The buyer agrees to indemnify, defend, and hold harmless Pure Health Peptides, its officers, employees, and agents from and against any and all claims, damages, losses, liabilities, costs, and expenses (including reasonable attorneys fees) arising out of or relating to the buyer’s use, handling, storage, or disposition of the product in any manner inconsistent with its research-use-only designation or applicable law.

Description

PE-22-28

Chemical Information:

  • Chemical Name: Spadin-derived heptapeptide (Gly-Val-Ser-Trp-Gly-Leu-Arg)
  • Molecular Formula: C₃₅H₅₅N₁₁O₉
  • Molecular Weight: ~773.89 g/mol
  • CAS Number: 1801959-12-5
  • Compound Class: Synthetic peptide (spadin analogue, heptapeptide)

Product Description:

PE-22-28 is a synthetic heptapeptide corresponding to residues 22–28 of spadin, a naturally occurring peptide fragment derived from the sortilin propeptide. The sequence represents a shortened analogue of the parent peptide. PE-22-28 is produced via solid-phase peptide synthesis (SPPS) and supplied as a lyophilized powder intended exclusively for controlled in-vitro laboratory research by qualified professionals. This product is not formulated for clinical, diagnostic, or therapeutic use.

Research Applications:

  • In-vitro investigation of TREK-1 (two-pore-domain potassium channel) modulation in cell-based assay systems
  • Laboratory studies of sortilin-derived peptide structure–activity relationships
  • Comparative evaluation of shortened spadin analogues for binding affinity and stability
  • Analytical method development and reference characterization for sequence-specific peptides

Storage and Handling:

  • Store lyophilized material at -20 °C for long-term stability
  • Reconstituted solutions should be stored at 2–8 °C and used promptly
  • Protect from light, heat, and repeated freeze–thaw cycles
  • Handle using appropriate laboratory safety and aseptic techniques

Product Specifications:

  • Purity: ≥99% (HPLC Certified)
  • Appearance: White to off-white lyophilized powder
  • Solubility: Soluble in suitable laboratory agents
  • Form: Lyophilized powder

Compliance Notice:

PE-22-28 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

Certificate of Analysis

Certificate of Analysis

At Pure Health Peptides, transparency is key. Every batch is third-party tested in the USA, with Certificates of Analysis (COAs) readily available for verification, giving researchers confidence in their work.

View Certifications

Frequently Asked Questions

What is PE-22-28?
PE-22-28 is a synthetic heptapeptide, Gly-Val-Ser-Trp-Gly-Leu-Arg (GVSWGLR), corresponding to residues 22-28 of spadin, a fragment of the sortilin propeptide. It has CAS number 1801959-12-5, molecular formula C35H55N11O9, and a molecular weight of approximately 773.9 g/mol. Pure Health Peptides supplies it as a lyophilized powder strictly for in vitro laboratory research.
Why is PE-22-28 called a spadin analogue?
Spadin is a naturally occurring peptide released from the sortilin propeptide. PE-22-28 corresponds to a short segment of that sequence (residues 22-28) and is described in the research literature as a spadin analogue studied as an inhibitor of the TREK-1 (KCNK2) potassium channel.
What is PE-22-28 studied for in research?
In controlled laboratory settings, PE-22-28 is studied as an inhibitor of the TREK-1 two-pore-domain potassium channel. Research literature reports that spadin-derived peptides of this class are examined in neuronal-signaling study models. These are research findings; all applications are non-clinical.
What are PE-22-28's chemical specifications, and what size does it come in?
PE-22-28 has CAS number 1801959-12-5, the molecular formula C35H55N11O9, and a molecular weight of approximately 773.9 g/mol (refer to the lot-specific Certificate of Analysis for the exact value). It is supplied as a lyophilized powder in a 10 mg size at greater than or equal to 98% purity (HPLC). Store in a cool, dry place away from light and moisture, and consult the Safety Data Sheet before handling.
Where can I buy PE-22-28, and is it third-party tested?
PE-22-28 is available from Pure Health Peptides as research-grade material in a 10 mg size at greater than or equal to 98% HPLC-verified purity. Every production lot is third-party tested in the US, with a lot-specific Certificate of Analysis available for verification.
Is PE-22-28 intended for human or clinical use?
No. PE-22-28 is for research use only and is not intended for human or veterinary use. It has not been evaluated by the FDA and is not a drug, food, cosmetic, or dietary supplement. It is supplied only to qualified research professionals for in vitro laboratory research, and KYC verification is required prior to fulfillment. Any use outside of controlled in vitro research is strictly prohibited.