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Cellular Growth & Signaling

IGF-1 LR3

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic peptide analog of human IGF-1, modified to enhance stability in controlled experimental environments. This analog incorporates an arginine substitution at position 3 and an extended amino acid sequence to alter its interaction profile in receptor-binding studies. In laboratory settings, IGF-1 LR3 is utilized in research involving peptide–receptor interactions, ligand binding dynamics, and intracellular signaling pathway analysis under defined in vitro conditions. This material is supplied in lyophilized powder form and is intended strictly for in vitro research and analytical applications.

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Product Usage: Not for Human or Veterinary UsePure Health Peptides products are supplied to qualified research professionals and institutional users for in vitro laboratory research only. KYC verification is required prior to order fulfillment, and we reserve the right to refuse orders that do not meet buyer qualification criteria. These products are not drugs, foods, cosmetics, diagnostic products, or dietary supplements, have not been evaluated by the FDA, and are not intended for human or animal use. Any such use is prohibited and may violate federal, state, or local law. By purchasing, the buyer represents and warrants that the product will be used solely for in vitro research. The buyer agrees to indemnify, defend, and hold harmless Pure Health Peptides, its officers, employees, and agents from and against any and all claims, damages, losses, liabilities, costs, and expenses (including reasonable attorneys fees) arising out of or relating to the buyer’s use, handling, storage, or disposition of the product in any manner inconsistent with its research-use-only designation or applicable law.

Description

Product Name:

IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3)

Chemical Information:
  • Molecular Formula: C400H625N111O115S9
  • Molecular Weight: 9117.53 g/mol
  • Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPAKSA
  • Molecular Structure:



Molecular Structure

Product Description:

IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic peptide analog of human IGF-1, modified to enhance stability in controlled experimental environments. This analog incorporates an arginine substitution at position 3 and an extended amino acid sequence to alter its interaction profile in receptor-binding studies. In laboratory settings, IGF-1 LR3 is utilized in research involving peptide–receptor interactions, ligand binding dynamics, and intracellular signaling pathway analysis under defined in vitro conditions. This material is supplied in lyophilized powder form and is intended strictly for in vitro research and analytical applications.

Research Applications:

IGF-1 LR3 is utilized in controlled research environments to support investigation of:

  • Insulin-like growth factor receptor (IGF-1R) binding and signaling pathway analysis
  • Ligand–receptor interaction modeling and affinity characterization
  • Intracellular signaling cascade evaluation associated with peptide ligands
  • Structure-function analysis of modified IGF-1 analogs
  • Stability, degradation, and analytical profiling in assay-based systems

All research applications are conducted in non-human, non-clinical experimental settings.

Storage and Handling:
  • Store lyophilized powder at -20°C.
  • Once reconstituted, store at 2-8°C and use promptly.
  • Maintain aseptic techniques during laboratory handling.
Product Specifications:
  • Purity: ≥99% (HPLC Certified)
  • Appearance: Lyophilized white powder
  • Solubility: Soluble in suitable laboratory agents

 

Compliance Notice:

IGF-1 LR3 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

Certificate of Analysis

Certificate of Analysis

At Pure Health Peptides, transparency is key. Every batch is third-party tested in the USA, with Certificates of Analysis (COAs) readily available for verification, giving researchers confidence in their work.

View Certifications

Frequently Asked Questions

What is IGF-1 LR3?
IGF-1 LR3 (Long Arg3 Insulin-like Growth Factor-1) is a synthetic 83-residue analog of human IGF-1, with molecular formula C400H625N111O115S9 and a molecular weight of 9117.53 g/mol. It differs from native IGF-1 by an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. Pure Health Peptides supplies it as a lyophilized powder strictly for in vitro laboratory research.
How is IGF-1 LR3 different from native IGF-1?
Native IGF-1 is a 70-amino-acid protein; IGF-1 LR3 is an 83-residue modified analog. Research literature reports that the arginine-3 substitution lowers its binding to IGF-binding proteins, which increases the free, active fraction and extends its half-life relative to native IGF-1. It is studied as a longer-acting IGF-1-receptor agonist.
What is IGF-1 LR3 studied for in research?
In controlled laboratory settings, IGF-1 LR3 is studied as an agonist of the type-1 IGF receptor (IGF-1R) and is widely used as a growth and proliferation supplement in cell-culture and bioprocessing research. These are in vitro research applications. Note: IGF-1 and its analogs appear on the World Anti-Doping Agency prohibited list; this material is supplied for laboratory research only.
What are IGF-1 LR3's chemical specifications, and what size does it come in?
IGF-1 LR3 has the molecular formula C400H625N111O115S9 and a molecular weight of 9117.53 g/mol (refer to the lot-specific Certificate of Analysis for the exact value). It is supplied as a lyophilized white powder in 1 mg and 2 mg vials at greater than or equal to 99% purity (HPLC). Store in a cool, dry place away from light and moisture.
Where can I buy IGF-1 LR3, and is it third-party tested?
IGF-1 LR3 is available from Pure Health Peptides as research-grade material in 1 mg and 2 mg vials at greater than or equal to 99% HPLC-verified purity. Every production lot is third-party tested in the US, with a lot-specific Certificate of Analysis available for verification.
Is IGF-1 LR3 intended for human or clinical use?
No. IGF-1 LR3 is for research use only and is not intended for human or veterinary use. It has not been evaluated by the FDA and is not a drug, food, cosmetic, or dietary supplement. It is supplied only to qualified research professionals for in vitro laboratory research, and KYC verification is required prior to fulfillment. Any use outside of controlled in vitro research is strictly prohibited.