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 Oncology & Cell Fate,  Regeneration & Aging Research

FOXO4-DRI

FOXO4-DRI (FOXO4 D-Retro-Inverso) is a synthetic peptide engineered in a D-retro-inverso configuration based on a defined peptide sequence. The retro-inverso design and D-residue composition are utilized in research to examine peptide stability and interaction characteristics in vitro. Supplied as a lyophilized powder, FOXO4-DRI is intended strictly for controlled laboratory research.

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Product Usage: Not for Human or Veterinary UsePure Health Peptides products are supplied to qualified research professionals and institutional users for in vitro laboratory research only. KYC verification is required prior to order fulfillment, and we reserve the right to refuse orders that do not meet buyer qualification criteria. These products are not drugs, foods, cosmetics, diagnostic products, or dietary supplements, have not been evaluated by the FDA, and are not intended for human or animal use. Any such use is prohibited and may violate federal, state, or local law. By purchasing, the buyer represents and warrants that the product will be used solely for in vitro research. The buyer agrees to indemnify, defend, and hold harmless Pure Health Peptides, its officers, employees, and agents from and against any and all claims, damages, losses, liabilities, costs, and expenses (including reasonable attorneys fees) arising out of or relating to the buyer’s use, handling, storage, or disposition of the product in any manner inconsistent with its research-use-only designation or applicable law.

Description

Product Name:

FOXO4-DRI (FOXO4 D-Retro-Inverso)

Chemical Information:
  • Molecular Formula: C228H388N86O64
  • Molecular Weight: ~5358 g/mol
  • Sequence: LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG (D-amino acids; retro-inverso)
  • Structure Class: Synthetic peptide (D-retro-inverso configuration)
Molecular Structure:



Molecular Structure

Product Description:

FOXO4-DRI (FOXO4 D-Retro-Inverso) is a synthetic peptide engineered in a D-retro-inverso configuration based on a defined peptide sequence. The retro-inverso design and D-residue composition are utilized in research to examine peptide stability and interaction characteristics in vitro. Supplied as a lyophilized powder, FOXO4-DRI is intended strictly for controlled laboratory research.

Research Applications:

FOXO4-DRI is utilized in controlled laboratory research settings for applications such as:

  • Evaluation of D-retro-inverso peptide behavior in stability and interaction assays
  • Investigation of peptide–protein binding interactions in defined assay systems
  • Comparative analysis of L- and D-configured peptide structures under controlled conditions
  • Development of in vitro assay systems for studying peptide interaction characteristics
Storage and Handling:
  • Store lyophilized powder at −20 °C until use
  • Once reconstituted, store at 2–8 °C and use promptly
  • Maintain aseptic technique during handling
Product Specifications:
  • Purity: ≥99% (HPLC/LC-MS Verified)
  • Appearance: Lyophilized white powder
  • Solubility: Soluble in suitable laboratory agents
Compliance Notice:

FOXO4-DRI is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

Certificate of Analysis

Certificate of Analysis

At Pure Health Peptides, transparency is key. Every batch is third-party tested in the USA, with Certificates of Analysis (COAs) readily available for verification, giving researchers confidence in their work.

View Certifications

Frequently Asked Questions

What is FOXO4-DRI?
FOXO4-DRI is a synthetic 46-amino-acid peptide built in a D-retro-inverso configuration, based on a sequence from the FOXO4 transcription factor (LTLRKEPASEIAQSILEAYSQNGWANRRSGGKRPPPRRRQRRKKRG, assembled from D-amino acids in reversed order; the C-terminal segment is a cell-penetrating tail). It has CAS number 2460055-10-9. It has molecular formula C228H388N86O64 and a molecular weight of approximately 5358 g/mol. Pure Health Peptides supplies it as a lyophilized powder strictly for in vitro laboratory research.
What does D-retro-inverso (DRI) mean?
A D-retro-inverso peptide is assembled from D-amino acids with the sequence written in reverse order. Research literature reports that this combination approximates the side-chain arrangement of the original L-peptide while making the backbone resistant to protease degradation, which is why DRI constructs are used as stable research analogs.
What is FOXO4-DRI studied for in research?
In controlled laboratory settings, FOXO4-DRI is studied as a peptide that interferes with the interaction between the FOXO4 protein and p53. Research literature reports that disrupting this interaction has been examined in models of senescent-cell biology. These are research findings; all applications are non-clinical.
What are FOXO4-DRI's chemical specifications, and what size does it come in?
FOXO4-DRI has CAS number 2460055-10-9, the molecular formula C228H388N86O64, and a molecular weight of approximately 5358 g/mol (refer to the lot-specific Certificate of Analysis for the exact value). It is supplied as a lyophilized white powder in 5 mg and 10 mg vials at greater than or equal to 99% purity (HPLC). Store in a cool, dry place away from light and moisture, and consult the Safety Data Sheet before handling.
Where can I buy FOXO4-DRI, and is it third-party tested?
FOXO4-DRI is available from Pure Health Peptides as research-grade material in 5 mg and 10 mg vials at greater than or equal to 99% HPLC-verified purity. Every production lot is third-party tested in the US, with a lot-specific Certificate of Analysis available for verification.
Is FOXO4-DRI intended for human or clinical use?
No. FOXO4-DRI is for research use only and is not intended for human or veterinary use. It has not been evaluated by the FDA and is not a drug, food, cosmetic, or dietary supplement. It is supplied only to qualified research professionals for in vitro laboratory research, and KYC verification is required prior to fulfillment. Any use outside of controlled in vitro research is strictly prohibited.