Eloralintide
Eloralintide is a synthetic 37-residue peptide analogue structurally derived from amylin, featuring several defined modifications to the parent sequence. The native Cys²–Cys⁷ disulfide bond is replaced with a methylene thioacetal bridge, three non-coded amino acids are incorporated (ornithine, α-methyl-phenylalanine, and N-methyl-asparagine), and a fatty diacid side chain is conjugated at the lysine residue in position 26. The C-terminus is amidated. These modifications make the compound a useful reference material for laboratory investigation of peptide stability, aggregation behavior, and the analytical characterization of lipidated peptides. This product is supplied as a lyophilized powder, intended exclusively for in vitro laboratory research by qualified professionals.
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Product Usage: Not for Human or Veterinary UsePure Health Peptides products are supplied to qualified research professionals and institutional users for in vitro laboratory research only. KYC verification is required prior to order fulfillment, and we reserve the right to refuse orders that do not meet buyer qualification criteria. These products are not drugs, foods, cosmetics, diagnostic products, or dietary supplements, have not been evaluated by the FDA, and are not intended for human or animal use. Any such use is prohibited and may violate federal, state, or local law. By purchasing, the buyer represents and warrants that the product will be used solely for in vitro research. The buyer agrees to indemnify, defend, and hold harmless Pure Health Peptides, its officers, employees, and agents from and against any and all claims, damages, losses, liabilities, costs, and expenses (including reasonable attorneys fees) arising out of or relating to the buyer’s use, handling, storage, or disposition of the product in any manner inconsistent with its research-use-only designation or applicable law.
Description
Product Name: Eloralintide
Chemical Information:
- CAS Number: 2883634-40-8
- Molecular Formula: C₂₀₁H₃₁₉N₄₉O₆₅S₂
- Molecular Weight: ~4526.1 g/mol (approximate; refer to Certificate of Analysis for exact value)
- Sequence: {γGlu}-CNTATCATG-{Orn}-LAE-{α-Me-Phe}-LVRSSN-{N-Me-Asn}-FGP-{Lys(γGlu-γGlu-C20 diacid)}-LPPTEVGSNTY-NH₂ (methylene thioacetal bridge: Cys²–Cys⁷)
- Peptide Length: 37 amino acids
- Compound Class: Synthetic lipidated peptide analogue (amylin-derived)
Product Description:
Eloralintide is a synthetic 37-residue peptide analogue structurally derived from amylin, featuring several defined modifications to the parent sequence. The native Cys²–Cys⁷ disulfide bond is replaced with a methylene thioacetal bridge, three non-coded amino acids are incorporated (ornithine, α-methyl-phenylalanine, and N-methyl-asparagine), and a fatty diacid side chain is conjugated at the lysine residue in position 26. The C-terminus is amidated. These modifications make the compound a useful reference material for laboratory investigation of peptide stability, aggregation behavior, and the analytical characterization of lipidated peptides. This product is supplied as a lyophilized powder, intended exclusively for in vitro laboratory research by qualified professionals.
Nomenclature Note:
This compound appears in the published scientific literature under the nonproprietary name eloralintide. The development code LY3841136 is used by a third-party clinical developer and is referenced here solely for literature cross-identification purposes. No affiliation, sponsorship, or endorsement is claimed or implied.
Research Applications:
- Receptor interaction characterization in defined in vitro assay systems
- Comparative stability analysis of thioacetal-bridged versus disulfide-bridged peptide structures
- Evaluation of aggregation and fibrillation propensity relative to unmodified amylin sequences under controlled conditions
- Chromatographic and mass spectrometric method development for lipidated peptides
- Structure–property relationship analysis of non-coded amino acid substitutions
Storage and Handling:
- Store the lyophilized powder at −20 °C
- Once reconstituted, store at 2–8 °C and use promptly
- Protect from light
- Maintain aseptic handling practices to ensure product quality and sterility
Product Specifications:
- Purity: ≥99% (HPLC Certified)
- Identity: Confirmed by LC-MS against theoretical molecular weight (refer to Certificate of Analysis)
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in suitable laboratory agents
Compliance Notice:
- Eloralintide is FOR RESEARCH USE ONLY as an analytical reference material. This compound corresponds structurally to an investigational substance currently under clinical development by a third-party pharmaceutical developer. It has not been approved by the FDA for any use. This research material is not the investigational product, is not manufactured under GMP conditions, is not equivalent to or a substitute for any investigational or approved pharmaceutical product, and is not intended for human or veterinary use. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.
Certificate of Analysis
At Pure Health Peptides, transparency is key. Every batch is third-party tested in the USA, with Certificates of Analysis (COAs) readily available for verification, giving researchers confidence in their work.
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