Cellular Growth & Signaling

ACE-031

Name: ACE-031
Price: 109.00 USD
Availability: InStock

ACE-031 is a recombinant fusion protein composed of the extracellular domain of the human activin receptor type IIB (ACVR2B) linked to the Fc region of human immunoglobulin G1 (IgG1). Unlike synthetic peptides, ACE-031 is a large glycosylated protein produced through mammalian cell expression systems rather than solid-phase peptide synthesis. This product is a research-grade reagent and is not manufactured under GMP conditions; it is not equivalent to, or a substitute for, any clinical- or pharmaceutical-grade material. It is supplied as a lyophilized protein intended exclusively for controlled in-vitro laboratory research by qualified professionals studying activin/TGF-β superfamily signaling pathways. This product is not formulated for clinical, diagnostic, or therapeutic use.

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Product Usage: Not for Human or Veterinary UsePure Health Peptides products are supplied to qualified research professionals and institutional users for in vitro laboratory research only. KYC verification is required prior to order fulfillment, and we reserve the right to refuse orders that do not meet buyer qualification criteria. These products are not drugs, foods, cosmetics, diagnostic products, or dietary supplements, have not been evaluated by the FDA, and are not intended for human or animal use. Any such use is prohibited and may violate federal, state, or local law. By purchasing, the buyer represents and warrants that the product will be used solely for in vitro research. The buyer agrees to indemnify, defend, and hold harmless Pure Health Peptides, its officers, employees, and agents from and against any and all claims, damages, losses, liabilities, costs, and expenses (including reasonable attorneys fees) arising out of or relating to the buyer’s use, handling, storage, or disposition of the product in any manner inconsistent with its research-use-only designation or applicable law.

Description

ACE-031

Chemical Information:

Chemical Name: ActRIIB-Fc fusion protein (Activin Receptor Type IIB / IgG1-Fc); also referenced as ACVR2B-Fc
Molecular Weight: ~80 kDa (homodimeric); ~58 kDa per glycosylated monomer (apparent, SDS-PAGE)
Structure: Recombinant homodimeric fusion protein; 343-amino-acid monomer with N-glycosylation sites
Compound Class: Recombinant fusion protein (soluble decoy receptor)

Product Description:

Research Applications:

In-vitro investigation of ActRIIB ligand-trap binding interactions within the TGF-β superfamily
Laboratory studies of myostatin (GDF-8) and activin signaling in cell-based assay systems
Comparative evaluation of fusion-protein decoy receptors and ligand-sequestration models
Analytical method development and reference characterization for recombinant fusion proteins

Storage and Handling:

Store lyophilized protein at -20 °C to -80 °C for long-term stability
Reconstituted solutions should be stored at 2–8 °C and used promptly; avoid repeated freeze–thaw cycles
Protect from light and elevated temperatures
Handle using appropriate laboratory safety and aseptic techniques

Product Specifications:

Purity: ≥95% (SDS-PAGE / SEC, refer to Certificate of Analysis)
Appearance: White lyophilized protein
Solubility: Soluble in suitable laboratory agents
Form: Lyophilized protein

Compliance Notice:

ACE-031 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA. Misuse of this product is strictly prohibited and may violate federal, state, or local laws. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

Certificate of Analysis

At Pure Health Peptides, transparency is key. Every batch is third-party tested in the USA, with Certificates of Analysis (COAs) readily available for verification, giving researchers confidence in their work.

View Certifications

Frequently Asked Questions

What is ACE-031?

ACE-031 is a recombinant fusion protein consisting of the extracellular ligand-binding domain of the activin receptor type IIB (ActRIIB, also written ACVR2B) fused to a human IgG1 Fc region. It is expressed as a glycosylated, disulfide-linked homodimer of approximately 80 kDa. Pure Health Peptides supplies it as a lyophilized powder strictly for in vitro laboratory research.

Is ACE-031 a peptide?

No. ACE-031 is not a short peptide - it is a recombinant Fc-fusion protein, defined by its amino-acid sequence and glycosylation rather than by a single small-molecule formula. For that reason it does not carry a discrete molecular formula, molecular weight, or CAS number in the way a small peptide does; it is characterized per lot by analytical methods appropriate to proteins.

What is ACE-031 studied for in research?

In controlled laboratory settings, ACE-031 is studied as a soluble decoy receptor. Research literature reports that the ActRIIB extracellular domain binds and sequesters ligands of the activin/TGF-beta family - including myostatin (GDF-8), activin A, and GDF-11 - reducing their signaling through the native receptor in study models. These are research findings; all applications are non-clinical.

What are ACE-031's chemical specifications, and what size does it come in?

ACE-031 is a recombinant glycoprotein of approximately 80 kDa (homodimeric), characterized per lot rather than by a fixed small-molecule formula (refer to the lot-specific Certificate of Analysis). It is supplied as a lyophilized powder in a 1 mg size. Store in a cool, dry place away from light and moisture, and consult the Safety Data Sheet before handling.

Where can I buy ACE-031, and is it third-party tested?

ACE-031 is available from Pure Health Peptides as research-grade material in a 1 mg size. Every production lot is third-party tested in the US, with a lot-specific Certificate of Analysis available for verification.

Is ACE-031 intended for human or clinical use?

No. ACE-031 is for research use only and is not intended for human or veterinary use. It has not been evaluated by the FDA and is not a drug, food, cosmetic, or dietary supplement. It is supplied only to qualified research professionals for in vitro laboratory research, and KYC verification is required prior to fulfillment. Any use outside of controlled in vitro research is strictly prohibited.